Effect of Budesonide Added to Saline Sinus Irrigation for Chronic Rhinosinusitis (2024)

Key Points

Question What is the effect of adding budesonide to large-volume, low-pressure saline sinus irrigation for patients with chronic rhinosinusitis (CRS)?

Findings In this randomized clinical trial of 80 patients with CRS, the average changes in Sino-Nasal Outcome Test (SNOT-22) scores, pretreatment to posttreatment, were 20.7 points for patients treated with budesonide and 13.6 points for those treated with saline alone.

Meaning The addition of budesonide to saline sinus irrigation results in clinically meaningful benefits for patients with CRS beyond the benefit experienced with saline alone.

Abstract

Importance Recent studies suggest that budesonide added to saline nasal lavage can be an effective treatment for patients with chronic rhinosinusitis (CRS).

Objective To evaluate the incremental effect of adding budesonide to large-volume, low-pressure saline sinus irrigation.

Design, Setting, and Participants This double-blind, placebo-controlled, randomized clinical trial was conducted at a quaternary care academic medical center between January 1, 2016, and February 16, 2017. A total of 80 adult patients with CRS were enrolled; 74 completed baseline assessments; and 61 remained in the trial to complete all analyses. Data analysis was conducted from March 2017 to August 2017.

Interventions All study participants were provided with a sinus rinse kit including saline and identical-appearing capsules that contained either budesonide (treatment group) or lactose (control group). Patients were instructed to dissolve the capsules in the saline and use the resulting solution to irrigate both nasal cavities, using half the solution for each cavity, once daily for 30 days.

Main Outcomes and Measures The primary outcome measure was the change in Sino-Nasal Outcome Test (SNOT-22) scores, pretreatment to posttreatment, in the budesonide group compared with the control group. Secondary outcome measures included patient-reported response to treatment, as measured with a modification of the Clinical Global Impressions scale, and endoscopic examination scored by the Lund-Kennedy grading system.

Results Of the 74 participants who completed baseline assessments (37 in each study arm), mean (SD) age, 51 (14.7) years, 50 (68%) were women. Of the 61 who remained in the trial to complete all analyses, 29 were randomized to budesonide treatment, and 32 to saline alone. The average change in SNOT-22 scores was 20.7 points for those in the budesonide group and 13.6 points for those in the control group, for a mean difference of 7 points in favor of the budesonide group (95% CI, −2 to 16). A total of 23 participants (79%) in the budesonide group experienced a clinically meaningful reduction in their SNOT-22 scores compared with 19 (59%) in the control group, for a difference of 20% (95% CI, −2.5% to 42.5%). The average change in endoscopic scores was 3.4 points for the budesonide group and 2.7 points for the control group. There were no related adverse events.

Conclusions and Relevance This study shows that budesonide in saline nasal lavage results in clinically meaningful benefits beyond the benefits of saline alone for patients with CRS. Given the imprecision in the treatment effect, further research is warranted to define the true effect of budesonide in saline nasal lavage.

Trial Registration ClinicalTrials.gov Identifier: NCT02696850

Introduction

Chronic rhinosinusitis (CRS) is a condition characterized by inflammation of the paranasal sinuses and lining of the nasal cavity for 12 weeks or more.1 It is primarily an inflammatory disease, with occasional exacerbations associated with infection. Though relatively common, the disease burden associated with CRS is substantial. Patients with CRS visit primary care clinicians twice as often as those without CRS and have 5 times as many prescriptions filled.2 A survey performed in 2007 found that approximately $8.3 billion is spent annually on CRS, primarily on prescription drugs and office-based care.3

The recommended medical management of CRS includes large-volume, low-pressure saline nasal lavage, systemic antibiotics, and topical nasal steroid sprays.4,5 While systemic antibiotics are useful to treat episodic exacerbations of CRS, there is little evidence to recommend them as long-term treatment. Nevertheless, antibiotics are often prescribed for CRS, and national surveys suggest a large degree of overutilization, which is associated with the development of serious adverse effects and resistant organisms.6-8 In contrast, topical nasal steroid sprays have been shown to be safe and effective in the long-term management of CRS.9-11 There is evidence, however, that the penetration of steroid beyond the nasal cavity and into the paranasal sinuses is limited, indicating that a novel delivery method is needed to improve intrasinus corticosteroid deposition.12-14

A recent systematic review by Thomas et al15 analyzed various ways to distribute topical therapeutics to the sinuses in patients with CRS. The authors found that large-volume, low-pressure irrigation devices resulted in better distribution to the nasal cavity and sinuses, especially after surgery, than low-volume devices. Large-volume, low-pressure saline sinus irrigation is a widely recommended treatment for CRS, which is low cost and has a high patient acceptance and benefit-to-risk margin.16-20

Three recent prospective cohort studies examined the use of large-volume, low-pressure, saline sinus irrigation to deliver budesonide, an anti-inflammatory glucocorticoid steroid used for the treatment of allergic rhinitis, nasal polyps, and chronic obstructive pulmonary disease.21-23 All 3 studies demonstrated statistically and clinically significant subjective improvement in sinus disease after treatment. In addition, 2 of the studies documented significant improvement in objective measures of sinus disease.21,23

The objective of the present study was to evaluate the effect of the addition of budesonide to large-volume, low-pressure saline sinus irrigation for patients with CRS in a double-blind, placebo-controlled, randomized clinical trial using both subjective and objective outcome measures.

Methods

Study Design and Participants

This study was a single-site, double-blinded, placebo-controlled, randomized clinical trial of patients with CRS. The trial protocol can be found in the Supplement, and the trial is registered at ClinicalTrials.gov (NCT02696850). The flow diagram of study enrollment and participation is shown in Figure 1. Men and women 18 years or older with a diagnosis of CRS were recruited from the Otolaryngology Clinic of the Washington University in St Louis School of Medicine from January 1, 2016, to February 16, 2017. The study was approved by Washington University’s Human Protection Research Office. All participants provided written informed consent.

Study participants were required to have inflammation of the sinuses, as documented by the recruiting physicians (J.S. and J.F.P.), for 12 weeks or longer and 2 or more of the following symptoms consistent with CRS: mucopurulent drainage (anterior, posterior, or both), nasal obstruction, facial pain-pressure-fullness, and decreased sense of smell.

Patients with a history of comorbid mucociliary conditions; antibiotic use in the 2 weeks prior to enrollment; sinus surgery in the 6 weeks prior to enrollment; cerebrospinal fluid leak; allergy to topical steroids; tuberculosis lung infection; and/or herpes eye infection were excluded. In addition, patients were excluded if they were pregnant, breastfeeding, or dependent on prolonged corticosteroid therapy for a comorbid condition.

Severity of overall comorbidity was assessed with the Adult Comorbidity Evaluation-27 (ACE-27) instrument.24 The ACE-27 is a valid comorbidity instrument that rates the degree of organ decompensation for a variety of different comorbid ailments and then generates an overall score (none, mild, moderate, or severe) based on the rating for individual ailments.

Interventions

All study participants were provided with an 8-ounce Sinus Rinse Regular Bottle Kit (NeilMed Pharmaceuticals Inc) and a 1-month supply of United States Pharmacopeia (USP) grade sodium chloride and sodium bicarbonate mixture. Participants were asked to either purchase distilled water or to boil tap water for 5 minutes to use with the saline irrigation. A randomized block design was generated by the study statistician (D.K.), and the study coordinator (S.K.) consecutively assigned participants to the treatment or control groups after enrollment. Participants randomized to the treatment group received 60 capsules of budesonide (0.5 mg/capsule), while participants randomized to the control group received 60 identical-appearing capsules of lactose. Each study bottle was assigned a number from 1 to 80 corresponding to the randomization schedule. The participants and all members of the study team except the study statistician were blinded to the randomization assignment. Participants were instructed to dissolve 2 capsules of the study drug into the sinus rinse bottle along with the saline, and to irrigate the left and right nasal cavity with one-half of the contents of the nasal rinse once daily for 30 days. All participants received verbal and written instructions on how to conduct the irrigation properly.

Patient-Reported Outcome Measures

The primary outcome measure was the intraparticipant change, pretreatment to posttreatment, in Sino-Nasal Outcome Test (SNOT-22) scores in the budesonide group compared with the control group. The SNOT-22 is a validated, patient-reported outcome measure that captures the physical, functional, and emotional consequences of rhinosinusitis.25 The SNOT-22 score is calculated as the sum of scores provided for each question and ranges from 0 to 110. All participants were asked to complete the SNOT-22 at baseline, 2 weeks, and after intervention (approximately 4 weeks after baseline). A minimal clinically important difference (MCID) in SNOT-22 scores was considered an improvement of at least 8.9 points, as described previously.25,26 Patients with a baseline SNOT-22 score below 9 were excluded because these patients would be unable to achieve MCID.

The secondary outcome measure was the patient-reported response to treatment, as measured with a modification of the Clinical Global Impressions (CGI) scale.27 The CGI questionnaire was given to all participants after intervention, and they were asked to rate their overall response to treatment using a 7-point Likert scale.

Objective Outcome Measure

Objective change in sinus disease was assessed with endoscopic examination by the recruiting otolaryngologist (J.S. and J.F.P.) at baseline and postintervention. Findings were recorded using the Lund-Kennedy grading system.28

Statistical Analysis

The sample size was estimated using preliminary data reported by Snidvongs et al.21 Using a 2-sided α of .05, with 80% power, it was estimated that a sample size of 32 participant per group (total n = 64) would be needed to detect an MCID of 9 points or greater in SNOT-22 scores from before to after treatment between the 2 treatment groups. Anticipating a 20% dropout rate, we set the sample size at 80 qualifying enrollees.

Descriptive statistics were used to summarize the demographic and clinical characteristics and assessments of the study population. The effect size was measured as the pretreatment to posttreatment change in SNOT-22 scores. The 95% confidence interval (CI) around the difference was calculated and used to assess for clinically meaningful differences between the 2 treatment groups. Recognizing the variability in individual responses and the distortion this variability can cause in summarizing treatment effects as a difference in means, the observed difference in the percentage of participants who achieved an MCID between the 2 treatment groups and the 95% CI around this percentage difference was calculated.29

A mixed general linear model approach was used to explore whether the magnitude and pattern of change in SNOT-22 scores between baseline and postintervention was different in the 2 treatment groups, and to estimate mean scores in the 2 groups after controlling for confounders.

All analyses were repeated within subgroups of nasal polyp and previous surgery participants. An interim analysis was performed after participant 32 was enrolled in the study to assess compliance with treatment and response to treatment. All statistical analyses were performed with SAS software, version 9.4 (SAS Institute Inc). Statistical significance was evaluated at the 2-sided α level of .05. Effect size and 95% CIs around the effect size are reported.

A total of 80 patients were enrolled in the study between January 1, 2016, and February 16, 2017, and were randomized to either budesonide (n = 40) or placebo (n = 40) saline nasal lavage. Six participants withdrew after randomization, and 74 completed baseline assessments and started their assigned interventions. Thirteen participants were lost to follow-up, and 61 completed the intervention and postintervention assessments (Figure 1).

The baseline characteristics of all participants are summarized in the Table. The mean (SD) age was 51 (14.7) years, and most participants were women (n = 50; 68%) and of white race (n = 67; 90%). Approximately half of the participants had no other comorbidities (n = 41; 53%), and 7 (9%) reported moderate or severe comorbidities.

There were 18 (25%) participants identified as having nasal polyps during medical examination and 21(28%) participants who reported having prior sinus surgery. The mean (SD) endoscopic score at initial visit was 5.3 (2.2) points, and the mean (SD) SNOT-22 score was 44.1 (18.5).

No significant differences were found between treatment groups in the distribution of baseline demographic characteristics, comorbidity, endoscopic scores, SNOT-22 scores, or history of sinus surgery. The percentage of participants with polyps was higher in the budesonide group (n = 12; 34%) than in the saline nasal lavage group (n = 6; 16%), for a difference of 18% (95% CI, −2 to 37).

There were 29 participants randomized to budesonide treatment and 32 to saline nasal lavage who completed postintervention study assessments. The mean (SD) change in SNOT-22 scores for participants in the budesonide group was 20.7 (17.9) points, and for those in the saline nasal lavage group, it was 13.6 (18.8) points, for a mean difference of 7 points in favor of the budesonide group (95% CI, −2 to 16) and a Cohen d of 0.39 (medium effect size) (Figure 2). A mixed within-between participants model was used to explore the change in SNOT-22 score from before to after intervention and to test whether this change was significantly different between the 2 study groups. The interaction effect between time of assessment and treatment group was not statistically significant. There was 1 patient who completed the study assessment but was not compliant with treatment in the budesonide group. When the noncompliant participant was excluded, a mean (SD) decrease in SNOT-22 scores of 22.1 (16.3) was observed in the budesonide group, corresponding to a mean difference in the change in SNOT-22 scores between treatment groups of 8.5 (95% CI, −0.6 to 18.0). The mean (SD) change in endoscopic scores from before to after intervention was 3.4 (2.3) points for participants in budesonide group and 2.7 (1.9) points for those in the placebo group. The average difference of the change between participants in the 2 groups was 0.7 points (95% CI, −0.6 to 2.0 points) in favor of the budesonide group.

A reduction of 9 or more points in SNOT-22 score was considered clinically meaningful. A total of 23 participants (79%) in the budesonide group experienced a reduction of 9 or more points in their SNOT-22 scores compared with 19 (59%) of those in the saline nasal lavage group, for an observed difference of 20% (95% CI, −2.5% to 42.5%) (Figure 3) and an odds ratio of 2.6 (95% CI, 0.84-8.2). When the noncompliant budesonide participant was excluded, 82% in the budesonide group achieved the MCID, for an observed difference of 23% (95% CI, 1%-45%) and an odds ratio of 3.15 (95% CI, 0.95-10.42) in favor of budesonide.

We investigated the role of polyps, history of sinus surgery, and comorbidity as potential confounders of the effect of budesonide treatment. Based on SNOT-22 scores, none of the variables were found to be confounders.

We explored the effect of budesonide treatment among the participants with nasal polyps. Among participants with no polyps, there was an average difference of 10.2 points (95% CI, −1.6 to 22.1) in the change in SNOT-22 scores between the budesonide (n = 18) and saline nasal lavage treatment (n = 26) groups. Among participants with polyps, there was an average difference of −4.1 points (95% CI, −20.4 to 12.2) in the change in SNOT-22 scores in the budesonide group (n = 10) compared with the saline nasal lavage group (n = 6) (Figure 4A).

In participants with a history of sinus surgery, a mean difference of −0.1 points (95% CI, −19.6 to 19.4) was observed in the change in SNOT-22 scores between the budesonide (n = 9) and saline nasal lavage groups (n = 9). In participants with no prior sinus surgery, a mean difference of 10.1 points (95% CI, −1.1 to 21.3) was observed in SNOT-22 scores between the budesonide (n = 20) and saline nasal lavage groups (n = 23) (Figure 4B).

Based on CGI, 24 participants (83%) in the budesonide group and 20 (67%) in the saline nasal lavage group self-reported that they were “minimally improved,” “much improved,” or “very much improved.” The observed difference in the percentage of participants who self-reported some degree of improvement between the 2 arms was 16% (95% CI, −6% to 38%) in favor of the budesonide group. There were no related adverse events in either intervention group.

Discussion

In this double-blind, placebo-controlled, randomized clinical trial, we found that the addition of 1 mg of budesonide to daily large-volume, low-pressure saline sinus irrigation for 1 month resulted in a clinically meaningful improvement in self-reported functional status and quality of life measures as well as objective measurements of CRS. The estimates of benefit were imprecise, and while the confidence interval does not exclude the possibility of no effect in the population, the upper bound of the confidence interval suggests that this effect can also be very strong. A greater benefit of budesonide was seen among patients with no history of surgery than in those who had undergone surgery, contrary to current understanding that surgical opening of the sinuses is required for medicated saline lavage to be effective. The presence of polyps was greater in the budesonide arm and was associated with a smaller improvement in symptoms with budesonide than when polyps were not present. Budesonide was well tolerated, and there were no reported adverse events associated with its use.

Currently, CRS is primarily treated as an infectious disease process with frequent administration of antibiotics. Research suggests that as much as 50% of the antibiotics prescribed for sinusitis may be inappropriate and associated with harm.7 As a result, multiple national organizations, including the Centers for Disease Control and Prevention (CDC), have begun antibiotic stewardship programs to measure and improve how antibiotics are prescribed by clinicians and used by patients.

Among specialists, there is a growing recognition that CRS may reflect a dysfunctional immune interplay between different host susceptibilities and environmental modifiers that are responsible for the chronic inflammatory response.30,31 This dysfunctional interplay creates targets for nonantibiotic therapy in chronic sinusitis. As there are a variety of different “phenotypes” of CRS, including patients with and without polyps, it is likely that there are a variety of different abnormalities within the innate and adaptive immune system or “endotypes” that can serve as targets for therapy.31 This new area of potential treatment is referred to as “biologic therapy,” and potential targets for therapy include epithelial cell–derived cytokines and IgE.

Saline nasal lavage has been shown to be an effective form of treatment for sinusitis and can be an effective delivery system for various therapeutics, including corticosteroids. Large-volume, low-pressure nasal lavage results in better distribution of therapeutics to the nasal cavity and sinuses than low-volume devices.15 Furthermore, these large-volume, low-pressure devices can mediate adverse effects of head position or nasal cavity anatomy on distribution.14,18 Saline nasal lavage is low cost and has both high patient acceptance and a high benefit-to-risk margin.17,19 Though the evidence regarding large-volume saline irrigation is promising, more high-quality evidence is needed to definitively establish its benefit compared with other forms of treatment such as nasal spray.16,27

The impact of budesonide added to saline nasal lavage for the treatment of CRS has been investigated with several prospective cohort studies. Sachanandani et al22 found clinically significant improvement in SNOT-20 scores and no change in adrenal function in 9 patients with CRS treated with saline nasal lavage with budesonide for 30 days. Steinke et al23 performed a similar study evaluating budesonide saline nasal irrigation treatment in 8 patients with CRS and demonstrated similar significant improvements in several objective and subjective sinus outcome measures. The conclusions from these studies, while promising, were largely speculative given the small sample sizes. Most recently, Snidvongs et al21 demonstrated significant and sustained objective and subjective clinical improvement in a large cohort of patients with CRS treated after endoscopic sinus surgery with topical steroid nasal irrigations. All 3 of these studies have been limited, however, by lack of a control group.

In the present trial, we observed a clinically significant benefit of budesonide among patients who had not had previous sinus surgery. These results are surprising and suggest that a large number of patients with CRS would benefit from budesonide without sinus surgery. The mechanism for this benefit is unclear as, previous research15 has suggested that the distribution of topical agents is significantly reduced without prior sinus surgery. The benefit found in the present study of budesonide among participants without a history of sinus surgery may be explained by many factors, including the ability of the budesonide molecule to stick to nasal mucosa and, through reduction of inflammation, allow penetration of the sinus cavities. We also observed that patients with nasal polyps had only a minor benefit of budesonide. Patients with nasal polyps may have reduced topical application and penetration of budesonide and thus less beneficial effects. Furthermore, patients with nasal polyps may have endotypes that are less responsive to the anti-inflammatory effects of the glucocorticosteroids.

Limitations

There are several limitations to this study. First, the duration of the trial was only 4 weeks and, given the long duration of symptoms and chronic nature of the condition for many participants, this may have been an insufficient amount of time to see the complete effect of the budesonide therapy. Compliance was assessed by patient self-report, as we did not have formal compliance assessments. Thus, we cannot be certain that participants completed the full 4 weeks of treatment. Despite these limitations, the observed magnitude of the benefit of budesonide was clinically significant, as evidenced by the effect size, and the true effect could be even greater, as evidenced by the upper bound of the 95% CIs. However, the low precision of the estimates of the effect, as demonstrated by the width of the 95% CIs, and the inclusion of the null for many of the comparisons, undermines our ability to make definitive conclusions from this trial. Furthermore, the size of certain subgroups, such as those with nasal polyps, was so small and unequally divided between the 2 treatment groups as to further prohibit definitive conclusions.

Conclusions

This study shows that the use of budesonide in large-volume, low-pressure saline nasal lavage results in clinically meaningful benefits for patients with CRS. Additional randomized clinical trials of the effect of budesonide in saline nasal lavage for those with CRS vs saline-alone controls and, furthermore, budesonide vs steroid nasal spray are needed and will help define the true effect of budesonide within unique patient subgroups.

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Article Information

Corresponding Author: Jay F. Piccirillo, MD, Department of Otolaryngology–Head and Neck Surgery, Washington University School of Medicine in St Louis, 660 S Euclid Ave, Campus Box 8115, St Louis, MO 63110 (piccirij@wustl.edu).

Accepted for Publication: March 19, 2018.

Published Online: June 7, 2018. doi:10.1001/jamaoto.2018.0667

Author Contributions: Dr Piccirillo had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Kallogjeri, Suko, Kukuljan, Schneider, Piccirillo.

Acquisition, analysis, or interpretation of data: Tait, Kallogjeri, Suko, Piccirillo.

Drafting of the manuscript: Tait, Kallogjeri, Piccirillo.

Critical revision of the manuscript for important intellectual content: Kallogjeri, Suko, Kukuljan, Schneider, Piccirillo.

Statistical analysis: Tait, Kallogjeri, Suko, Piccirillo.

Obtained funding: Piccirillo.

Administrative, technical, or material support: Suko, Kukuljan, Schneider, Piccirillo.

Supervision: Piccirillo.

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Piccirillo receives royalty income for use of the SNOT-22 instrument. NeilMed provided the rinse bottles and saline solution. No other disclosures are reported.

Funding/Support: Funding for this research was provided by unrestricted research funds from the Clinical Outcomes Research Office, Department of Otolaryngology–Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions. We thank M. Allison Ogden, MD, Andrew J. Drescher, MD, Stanley E. Thawley, MD, and Maggie Wallace, FPN, for assisting with patient recruitment for the study. We acknowledge the NeilMed Company for providing the NeilMed bottles and saline. No contributors were compensated for their contributions.

References

1.

Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis.Otolaryngol Head Neck Surg. 2015;152(2)(suppl):S1-S39.PubMedGoogle Scholar

2.

Ray NF, Baraniuk JN, Thamer M, et al. Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders.J Allergy Clin Immunol. 1999;103(3 Pt 1):408-414.PubMedGoogle Scholar

3.

Bhattacharyya N. Incremental healthcare utilization and expenditures for allergic rhinitis in the United States.Laryngoscope. 2011;121(9):1830-1833.PubMedGoogle Scholar

4.

Dass K, Peters AT. Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter.Curr Allergy Asthma Rep. 2016;16(4):29.PubMedGoogle Scholar

5.

Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists.Rhinology. 2012;50(1)(suppl 23):1-12.PubMedGoogle Scholar

6.

Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09.J Antimicrob Chemother. 2014;69(1):234-240.PubMedGoogle Scholar

7.

Fleming-Dutra KE, Hersh AL, Shapiro DJ, et al. Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.JAMA. 2016;315(17):1864-1873.PubMedGoogle Scholar

8.

Harvey RJ, Lund VJ. Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research.Rhinology. 2007;45(1):3-13.PubMedGoogle Scholar

9.

Kalish LH, Arendts G, Sacks R, Craig JC. Topical steroids in chronic rhinosinusitis without polyps: a systematic review and meta-analysis.Otolaryngol Head Neck Surg. 2009;141(6):674-683.PubMedGoogle Scholar

10.

Snidvongs K, Kalish L, Sacks R, Craig JC, Harvey RJ. Topical steroid for chronic rhinosinusitis without polyps.Cochrane Database Syst Rev. 2011;(8):CD009274.PubMedGoogle Scholar

11.

Rudmik L, Hoy M, Schlosser RJ, et al. Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations.Int Forum Allergy Rhinol. 2013;3(4):281-298.PubMedGoogle Scholar

12.

Harvey RJ, Goddard JC, Wise SK, Schlosser RJ. Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation.Otolaryngol Head Neck Surg. 2008;139(1):137-142.PubMedGoogle Scholar

13.

Miller TR, Muntz HR, Gilbert ME, Orlandi RR. Comparison of topical medication delivery systems after sinus surgery.Laryngoscope. 2004;114(2):201-204.PubMedGoogle Scholar

14.

Orlandi RR, Kingdom TT, Hwang PH, et al. International consensus statement on allergy and rhinology: rhinosinusitis.Int Forum Allergy Rhinol. 2016;6(suppl 1):S22-S209.PubMedGoogle Scholar

15.

Thomas WW III, Harvey RJ, Rudmik L, Hwang PH, Schlosser RJ. Distribution of topical agents to the paranasal sinuses: an evidence-based review with recommendations.Int Forum Allergy Rhinol. 2013;3(9):691-703.PubMedGoogle Scholar

16.

Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis.Cochrane Database Syst Rev. 2007;(3):CD006394.PubMedGoogle Scholar

17.

van den Berg JW, de Nier LM, Kaper NM, et al. Limited evidence: higher efficacy of nasal saline irrigation over nasal saline spray in chronic rhinosinusitis--an update and reanalysis of the evidence base.Otolaryngol Head Neck Surg. 2014;150(1):16-21.PubMedGoogle Scholar

18.

Rabago D, Zgierska A, Mundt M, Barrett B, Bobula J, Maberry R. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial.J Fam Pract. 2002;51(12):1049-1055.PubMedGoogle Scholar

19.

Pynnonen MA, Mukerji SS, Kim HM, Adams ME, Terrell JE. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial.Arch Otolaryngol Head Neck Surg. 2007;133(11):1115-1120.PubMedGoogle Scholar

20.

Rabago D, Barrett B, Marchand L, Maberry R, Mundt M. Qualitative aspects of nasal irrigation use by patients with chronic sinus disease in a multimethod study.Ann Fam Med. 2006;4(4):295-301.PubMedGoogle Scholar

21.

Snidvongs K, Pratt E, Chin D, Sacks R, Earls P, Harvey RJ. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis.Int Forum Allergy Rhinol. 2012;2(5):415-421.PubMedGoogle Scholar

22.

Sachanandani NS, Piccirillo JF, Kramper MA, Thawley SE, Vlahiotis A. The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis.Arch Otolaryngol Head Neck Surg. 2009;135(3):303-307.PubMedGoogle Scholar

23.

Steinke JW, Payne SC, Tessier ME, Borish LO, Han JK, Borish LC. Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis.J Allergy Clin Immunol. 2009;124(6):1352-4.e7.PubMedGoogle Scholar

24.

Piccirillo JF, Tierney RM, Costas I, Grove L, Spitznagel EL Jr. Prognostic importance of comorbidity in a hospital-based cancer registry.JAMA. 2004;291(20):2441-2447.PubMedGoogle Scholar

25.

Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP. Psychometric validity of the 22-item Sinonasal Outcome Test.Clin Otolaryngol. 2009;34(5):447-454.PubMedGoogle Scholar

26.

Smith KA, Smith TL, Mace JC, Rudmik L. Endoscopic sinus surgery compared to continued medical therapy for patients with refractory chronic rhinosinusitis.Int Forum Allergy Rhinol. 2014;4(10):823-827.PubMedGoogle Scholar

27.

Busner J, Targum SD. The Clinical Global Impressions scale: applying a research tool in clinical practice.Psychiatry (Edgmont). 2007;4(7):28-37.PubMedGoogle Scholar

28.

Lund VJ, Kennedy DW. Staging for rhinosinusitis.Otolaryngol Head Neck Surg. 1997;117(3 Pt 2):S35-S40.PubMedGoogle Scholar

29.

Guyatt GH, Osoba D, Wu AW, Wyrwich KW, Norman GR; Clinical Significance Consensus Meeting Group. Methods to explain the clinical significance of health status measures.Mayo Clin Proc. 2002;77(4):371-383.PubMedGoogle Scholar

30.

Akdis CA, Bachert C, Cingi C, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.J Allergy Clin Immunol. 2013;131(6):1479-1490.PubMedGoogle Scholar

31.

Lam K, Kern RC, Luong A. Is there a future for biologics in the management of chronic rhinosinusitis?Int Forum Allergy Rhinol. 2016;6(9):935-942.PubMedGoogle Scholar

Effect of Budesonide Added to Saline Sinus Irrigation for Chronic Rhinosinusitis (2024)
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